化学
氨基酸
酪氨酸
芳香族氨基酸
化学改性
苯丙氨酸
色氨酸
组氨酸
半胱氨酸
生物分子
赖氨酸
生物化学
酶
作者
Bishwajit Paul,Modhu Sudan Maji,Susanta Bhunia,Manasa Purushotham,Ganesh Karan
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-05-11
卷期号:55 (22): 3701-3724
被引量:4
摘要
Abstract The chemical diversification of biomolecules set forth a significant area of research that constitutes an important intersection between chemistry and biology. Amino acids and peptides are the fundamental building blocks of proteins and play essential roles in all living organisms. While significant efforts have been geared toward the chemical modification of amino acid residues, particularly the functionalization of reactive functional groups such as lysine NH2 and cysteine SH, the exploration of the aromatic amino acid residues of tryptophan, tyrosine, phenylalanine, and histidine has been relatively limited. Therefore, this review highlights strategies for the side-chain functionalization of these four aromatic amino acids in peptides, with a focus on elucidating the underlying mechanisms. We have also illustrated the use of these modifications in the chemical and biological realm. 1 Introduction 2 Tryptophan Modifications 3 Tyrosine Modifications 4 Phenylalanine Modifications 5 Histidine Modifications 6 Perspectives and Future Outlook
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