四嗪
化学
生物结合
组合化学
产量(工程)
标签
块(置换群论)
纳米技术
有机化学
生物化学
材料科学
几何学
数学
冶金
作者
Lukas Hoff,Simon Schnell,Élie Benchimol,Fabio Pereira Foutinho,Andrea Tomio,Michel Rickhaus,Karl Gademann
标识
DOI:10.1002/hlca.202200198
摘要
Abstract In this synthetic procedure, a seven‐step protocol for the preparation of monosubstituted 3‐bromo‐1,2,4,5‐tetrazine is presented. The procedure features efficient transformations and purification methods starting from commercially readily available starting materials and affords the title compound on a gram scale with 13 % overall yield in reliable purity (>97 %). Detailed experimental procedures, supported by images and additional notes, allow the preparation of a valuable advanced building block, enabling further applications in bioconjugation, protein labelling, bio‐orthogonal chemistry, heterocycle syntheses, high energy materials, and drug release, among others.
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