Sheet-like 2D Manganese(IV) Complex with High Photothermal Conversion Efficiency

化学 光热治疗 配体(生物化学) 体内 水溶液 顺磁性 光化学 辐照 纳米技术 物理化学 材料科学 有机化学 受体 核物理学 生物化学 生物技术 物理 生物 量子力学
作者
Ye Xu,Chao Li,Xiaoyu Wu,Ming‐Xing Li,Yun‐Sheng Ma,Hong Yang,Qingdao Zeng,Jonathan L. Sessler,Zhao‐Xi Wang
出处
期刊:Journal of the American Chemical Society [American Chemical Society]
卷期号:144 (41): 18834-18843 被引量:18
标识
DOI:10.1021/jacs.2c04734
摘要

We report a stable, water-soluble, mononuclear manganese(IV) complex [MnIV(H2L)]·5H2O (Mn-HDCL) that acts as an efficient photothermal material. This system is based on a hexahydrazide clathrochelate ligand (L/HDCL) and is obtained via an efficient one-pot templated synthesis that avoids the need for harsh reaction conditions. Scanning tunneling microscopy images reveal that Mn-HDCL exists as a 2D sheet-like structure. In Mn-HDCL, the manganese(IV) ion is trapped within the cavity of the cage-like ligand. This effectively shields the Mn(IV) ion from the external environment while providing adequate water solubility. As a result of orbital transitions involving the coordinated manganese(IV) ion, as well as metal-to-ligand charge transfer effects, Mn-HDCL possesses a large extinction coefficient and displays a photothermal performance comparable to single-wall carbon nanotubes in the solid state. A high photothermal conversion efficiency (ca. 71%) was achieved in aqueous solution when subjected to near-infrared 730 nm laser photo-irradiation. Mn-HDCL is paramagnetic and provides a modest increase in the T1-weighted contrast of magnetic resonance images both in vitro and in vivo. Mn-HDCL was found to target tumors passively and allow tumor margins to be distinguished in vivo in a mouse model. In addition, it also exhibited an efficient laser-triggered photothermal therapy effect in vitro and in vivo. We thus propose that Mn-HDCL could have a role to play as a tumor-targeting photothermal sensitizer.
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