再生(生物学)
材料科学
硅酸钙
钙
脚手架
硅酸盐
骨愈合
锌
原位
生物医学工程
化学工程
化学
细胞生物学
解剖
复合材料
冶金
有机化学
生物
医学
工程类
作者
Guowen Qian,Tingting Wu,Zhaozhen Wang,Bo Yu,Jiandong Ye
标识
DOI:10.1088/1748-605x/ad3704
摘要
Abstract Rapid bone regeneration in implants is important for successful transplantation. In this regard, we report the development of calcium silicate/zinc silicate (CS/ZS) dual-compound-incorporated calcium phosphate cement (CPC) scaffolds with a three-dimensional poly (lactic-co-glycolic acid) network that synergistically promote bone regeneration. In vitro results demonstrated that the incorporation of CS/ZS dual compounds into the CPC significantly promoted the osteogenic differentiation of stem cells compared to the addition of CS or ZS alone. Moreover, the bone-regeneration efficacy of the composite scaffolds was validated by filling in femur condyle defects in rabbits, which showed that the scaffolds with CS and ZS possessed a great bone repair effect, as evidenced by more new bone formation and a faster scaffold biodegradation compared to the scaffold with CS alone.
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