HMGB1
可药性
组蛋白
生物标志物
染色质
生物
癌症研究
医学
免疫学
炎症
生物化学
DNA
基因
作者
Richa Raj,Pingping Shen,Boyang Yu,Jian Zhang
标识
DOI:10.1080/13543776.2024.2338105
摘要
Introduction HMGB1 is a non-histone chromatin protein released or secreted from cells in response to tissue damage or infection. Extracellular HMGB1, as a crucial immunomodulatory factor, binds with several different receptors to innate inflammatory responses that aggravate acute and chronic liver diseases. The increased levels of HMGB1 have been reported in various liver diseases, highlighting that it represents a potential biomarker and druggable target for therapeutic development.
科研通智能强力驱动
Strongly Powered by AbleSci AI