Visible Light‐Mediated Defluorination to Access 1,1‐Difluoro‐1,3‐Enynes

Abstract Herein, a visible light‐mediated defluorination reaction to access 1,1‐difluoro‐1,3‐enynes is described. Compared with previous studies, this protocol employs more readily accessible acids as a radical precursor under redox‐neutral conditions. Moreover, the reaction exhibits high compatibility with diverse primary, secondary and tertiary acids, especially natural amino acids and drug‐derived acids. Preliminary mechanistic investigations reveal that a radical pathway is involved in the catalytic cycle.