Efficient and Scalable Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones by Benzylic Oxidation of Tetrahydroisoquinoline Derivatives using Cerium Ammonium Nitrate (CAN)

Herein, we report an efficient method for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by oxidation of tetrahydroisoquinoline derivatives using cerium ammonium nitrate (CAN) and NaBrO3.