Electroactive injectable hydrogel based on oxidized sodium alginate and carboxymethyl chitosan for wound healing

生物相容性 伤口愈合 壳聚糖 材料科学 自愈水凝胶 电活性聚合物 化学 聚合物 纳米技术 生物医学工程 高分子化学 有机化学 复合材料 外科 医学 冶金
作者
Lin Zhao,Zhipan Feng,Yang Lyu,Jueying Yang,Lizhi Lin,Haochen Bai,Yujing Li,Yongqiang Feng,Yu Chen
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:230: 123231-123231 被引量:47
标识
DOI:10.1016/j.ijbiomac.2023.123231
摘要

Electroactive hydrogel is of great significance in restoring wound currents, promoting cell proliferation, and accelerating the wound healing process. However, the poor dispersity and underlying toxicity of electronic conductive fillers and high concentration of ionic conductors in traditional electroactive hydrogel limited its application in medical care. Herein, an electroactive oxidized sodium alginate/carboxymethyl chitosan/silver nanoparticles (OSA/CMCS/AgNPs) hydrogel was constructed with no additional conductive fillers or synthesized conductive polymers being added, in which the dynamic imine bonds were rapidly formed between aldehyde groups in OSA and amino groups in CMCS, and AgNPs were further in situ formed by UV irradiation. The electroactive hydrogel exhibited the injectable property, strong self-healing ability, excellent biocompatibility, and high antibacterial activities. Moreover, the electroactive hydrogel can significantly promote the proliferation of L929 cells under electrical stimulation. Furthermore, the electroactive hydrogel was proved to significantly accelerate the wound healing process in the full-thickness skin defect model, exhibiting anti-inflammation, promoting the fibroblasts proliferation, angiogenesis, and collagen deposition under electrical stimulation. In summary, the current work explored a novel strategy to construct the polysaccharides-based electroactive hydrogel with good biocompatibility and multi-functions, which is promising to be used in deep wound treatment.
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