医学
血肿
灌注
薄壁组织
灌注扫描
放射科
梗塞
冲程(发动机)
磁共振成像
缺血
曲线下面积
心脏病学
内科学
病理
心肌梗塞
工程类
机械工程
作者
X Chen,Jie Xu,Shunyuan Guo,Sheng Zhang,Huiyuan Wang,Panpan Shen,Yafei Shang,Mingming Tan,Geng Yang
摘要
Abstract Background and Purpose Parenchymal hematoma is a dreaded complication of mechanical thrombectomy after acute ischemic stroke. This study evaluated whether blood‐brain barrier permeability measurements based on CT perfusion could be used as predictors of parenchymal hematoma after successful recanalization and compared the predictive value of various permeability parameters in patients with acute ischemic stroke. Methods We enrolled 53 patients with acute ischemic stroke who underwent mechanical thrombectomy and achieved successful recanalization. Each patient underwent CT, CT angiography, and CT perfusion imaging before treatment. We used relative volume transfer constant (r K trans ) values, relative permeability–surface area product (r P · S ), and relative extraction fraction (r E ) to evaluate preoperative blood‐brain barrier permeability in the delayed perfusion area. Results Overall, 22 patients (37.7%) developed hemorrhagic transformation after surgery, including 10 patients (16.9%) with hemorrhagic infarction and 11 patients (20.8%) with parenchymal hematoma. The r P · S , r K trans , and r E of the hypoperfusion area in the parenchymal hematoma group were significantly higher than those in the hemorrhagic infarction and no‐hemorrhage transformation groups ( p < .01). We found that r E and r P · S were superior to r K trans in predicting parenchymal hematoma transformation after thrombectomy ( P · S area under the curve [AUC] .844 vs. r K trans AUC .753, z = 2.064, p = .039; r E AUC .907 vs. r K trans AUC .753, z = 2.399, p = .017). Conclusions Patients with parenchymal hematoma after mechanical thrombectomy had higher blood‐brain barrier permeability in hypoperfusion areas. Among blood‐brain barrier permeability measurement parameters, r P · S and r E showed better accuracy for parenchymal hematoma prediction.
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