西塔
生物
免疫系统
癌症研究
脱甲基酶
组蛋白
染色质
主要组织相容性复合体
细胞生物学
基因
免疫学
遗传学
MHC II级
作者
Daphne Dupéré-Richer,Alberto Riva,Sayantan Maji,Benjamin G. Barwick,Heidi Casellas Román,Amin Sobh,Gabrielle Quickstad,Jianping Li,Umasankar De,Crissandra Piper,Marta Kulis,Teresa Ezponda,José I. Martín‐Subero,Giovanni Tonon,Weizhou Zhang,Constantine S. Mitsiades,Lawrence Boise,Richard L. Bennett,Jonathan D. Licht
标识
DOI：10.1101/2024.02.12.579179
摘要
The histone H3K27 demethylase KDM6A is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to facilitate genome wide studies. KDM6A binds genes associated with immune recognition and cytokine signaling. Most importantly, KDM6A binds and activates
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