化学
烯烃
电泳剂
区域选择性
催化作用
烷基
镍
卤化物
烷基化
还原消去
功能群
有机化学
组合化学
聚合物
作者
Huixia Yang,Z. Zhang,Panting Cao,Tao Yang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-02-03
卷期号:26 (6): 1190-1195
标识
DOI:10.1021/acs.orglett.3c04207
摘要
A Ni-catalyzed reductive dialkylation of 8-aminoquinoline-tethered aliphatic alkenes with two unactivated alkyl electrophiles is disclosed here. Key to the development of this transformation is the combination of primary alkyl (pseudo)halides and secondary alkyl iodides that produce products in a single regioselective manner. The reaction exhibits good functional group compatibility, and its synthetic utility was demonstrated by the concise synthesis of the precursors of biologically relevant molecules.
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