神经科学
前额叶皮质
抑制性突触后电位
神经传递
兴奋性突触后电位
海马体
三叉神经痛
生物神经网络
促肾上腺皮质激素释放激素
医学
化学
心理学
内科学
受体
下丘脑
认知
作者
Su‐Su Lv,Xue‐Jing Lv,Yaqi Cai,Xin-Yu Hou,Zhi-Zhe Zhang,Guohong Wang,Liqiang Chen,Ning Lü,Yu‐Qiu Zhang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-01-19
卷期号:10 (3)
被引量:3
标识
DOI:10.1126/sciadv.adj4196
摘要
Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits and mechanisms underlying this association are poorly understood. Here, we identified a dedicated neural circuit from the ventral hippocampus (vHPC) to the medial prefrontal cortex (mPFC) that mediates TN-related anxiodepression. We found that TN caused an increase in excitatory synaptic transmission from vHPC CaMK2A neurons to mPFC inhibitory neurons marked by the expression of corticotropin-releasing hormone (CRH). Activation of CRH + neurons subsequently led to feed-forward inhibition of layer V pyramidal neurons in the mPFC via activation of the CRH receptor 1 (CRHR1). Inhibition of the vHPC CaMK2A -mPFC CRH circuit ameliorated TN-induced anxiodepression, whereas activating this pathway sufficiently produced anxiodepressive-like behaviors. Thus, our studies identified a neural pathway driving pain-related anxiodepression and a molecular target for treating pain-related psychiatric disorders.
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