Effectiveness of Combination Chemotherapy With Docetaxel, Nedaplatin, and 5-Fluorouracil for Advanced and Recurrent Esophageal Cancer

奈达铂 多西紫杉醇 医学 内科学 氟尿嘧啶 化疗 肿瘤科 食管癌 白细胞减少症 中性粒细胞减少症 养生 癌症 外科 顺铂
作者
Makoto Sohda,Keigo Hara,KENGO KURIYAMA,K. Tateno,SHINTARO UCHIDA,Takayoshi Watanabe,Yuta Shibasaki,HIDEYUKI SAITO,Nobuhiro Nakazawa,Akihiko Sano,Makoto Sakai,TAKEHIKO YOKOBORI,Hiroomi Ogawa,Ken Shirabe,Hiroshi Saeki
出处
期刊:Anticancer Research [Anticancer Research USA Inc.]
卷期号:44 (3): 1309-1315
标识
DOI:10.21873/anticanres.16926
摘要

Background/Aim: Chemotherapy and immunotherapy have been recently developed as potentially useful first-line treatments for unresectable, advanced, or recurrent esophageal cancer. We performed a retrospective study of the therapeutic effectiveness of triplet chemotherapy with docetaxel, nedaplatin, and 5-fluorouracil therapy for advanced, recurrent, and unresectable advanced esophageal cancer at our hospital and compared the regimen's results with those of current and possible future treatment options. Patients and Methods: The study cohort comprised 101 patients who received docetaxel, nedaplatin, and 5-fluorouracil for advanced or recurrent esophageal cancer at Gunma University from May 2008 to December 2017. We retrospectively evaluated the results of this combination chemotherapy and postulated future treatment strategies. Results: The overall response and disease control rates, the latter including stable disease, for docetaxel, nedaplatin, and 5-fluorouracil were 33.6% and 61.4%, respectively. The median overall survival and progression-free survival were 12.26 months and 5.1 months, respectively. In patients with recurrence, the median overall and progression-free survivals were 14.97 months (449 days) and 5.1 months (152 days), respectively. No study patients developed acute kidney injury and there were no treatment-related deaths. However, leukopenia and neutropenia were frequent hematologic toxicities. Conclusion: Treatment with docetaxel, nedaplatin, and 5-fluorouracil for advanced or recurrent esophageal cancer is particularly useful for recurrent cases and has the advantage of not causing severe renal dysfunction.

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