Modes and motifs in multicellular communication

Signaling pathways feature multiple interacting ligand and receptor variants, which are thought to act in a combinatorial manner to elicit different cellular responses. Transcriptome analyses now suggest that many signaling pathways use their components in combinations that are surprisingly often shared between otherwise dissimilar cell states. Signaling pathways feature multiple interacting ligand and receptor variants, which are thought to act in a combinatorial manner to elicit different cellular responses. Transcriptome analyses now suggest that many signaling pathways use their components in combinations that are surprisingly often shared between otherwise dissimilar cell states. Combinatorial expression motifs in signaling pathwaysGranados et al.Cell GenomicsJanuary 10, 2024In BriefGranados et al. identify pathway expression motifs from single-cell gene expression data, which are found across core cell signaling pathways. Different cell types were found to operate the same pathways but with distinct functional modes that can remain stable or change dynamically during biological processes. Full-Text PDF Open Access