EBV and MS: The evidence is growing stronger

Autoimmune cross-reaction of specific antibodies to Epstein-Barr virus (EBV) has been associated with development of multiple sclerosis (MS). In this issue of Cell, Vietzen et al. identify additional immunological regulatory mechanisms that protect against autoimmunity in healthy people but are reduced in MS cases. The results confirm the link between EBV and MS. Autoimmune cross-reaction of specific antibodies to Epstein-Barr virus (EBV) has been associated with development of multiple sclerosis (MS). In this issue of Cell, Vietzen et al. identify additional immunological regulatory mechanisms that protect against autoimmunity in healthy people but are reduced in MS cases. The results confirm the link between EBV and MS. Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosisVietzen et al.CellDecember 12, 2023In BriefHuman genetic pre-disposition, as well as human cytomegalovirus and Epstein-Barr virus-encoded genetic variants, affect distinct protective immune responses against autoimmune cells and define the individual risk for multiple sclerosis. Full-Text PDF Open Access