表观遗传学
基底细胞癌
皮肤癌
DNA甲基化
表型
生物
阳光照射
基础(医学)
老化
医学
病理
癌症
遗传学
基底细胞
皮肤病科
内分泌学
基因
基因表达
胰岛素
作者
Richie Jeremian,Alexandra Malinowski,Yuliya Lytvyn,Jorge R. Georgakopoulos,Anastasiya Muntyanu,Asfandyar Mufti,Philippe Lefrançois,Jensen Yeung,Ivan V. Litvinov
摘要
This study investigated epigenetic changes, specifically epigenetic ageing, in an adult cohort of healthy individuals using five validated epigenetic clock algorithms and a DNA methylation-based estimator of telomere length. Our study demonstrated significant biologic/epigenetic age dysregulation in sun-exposed vs. sun-protected dermal and epidermal skin, with a strong correlation to the validated Helfrich skin photoageing scale, occurring in patterns that overlap with those seen in basal cell carcinoma. This work highlights the power of novel epigenetic analyses in studying photoageing and skin cancer predisposition.
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