邻苯二甲酸盐
不良结局途径
产前暴露
不利影响
医学
自闭症
维生素D与神经学
维生素
童年不良经历
怀孕
心理学
发展心理学
临床心理学
精神科
内分泌学
内科学
生物
妊娠期
化学
遗传学
心理健康
有机化学
计算生物学
作者
Hui Gao,Cheng Zhang,Beibei Zhu,Menglong Geng,Juan Tong,Zhen Zhan,Yi Zhang,De Wu,Kun Huang,Fangbiao Tao
出处
期刊:Eco-environment & health
日期:2024-02-01
标识
DOI:10.1016/j.eehl.2024.01.007
摘要
The association between prenatal phthalate mixture exposure and the risk of autism spectrum disorder (ASD) in children, as well as the potential mechanism and impact of maternal vitamin D, remains unclear. We analyzed data from 3,209 mother–child pairs. The associations between prenatal phthalate exposure and autistic traits in children aged 1.5, 3.0, 5.0, and 6.0 years were explored. Furthermore, the modifying effects of maternal vitamin D and the adverse outcome pathway (AOP), which elucidates the contribution of phthalates to ASD, were estimated.Exposure to a phthalate mixture was associated with an increased risk of ASD in children aged 1.5 to 6.0 years. For mothers with 25(OH)D deficiency, an exposure‒response relationship was observed between phthalate mixtures in early to mid-pregnancy and autistic traits in children aged 3.0 years. However, this association was not observed for mothers with sufficient prenatal 25(OH)D levels. The potential mechanism of action of di(2-ethylhexyl) phthalate (DEHP) exposure may involve affecting GRIN2B, inhibiting NMDAR in the postsynaptic membrane, disrupting synaptic function, and impairing learning and memory, ultimately leading to ASD development. Importantly, maternal vitamin D supplementation was demonstrated to mitigate the risk of ASD associated with phthalate exposure. Reducing phthalate exposure during pregnancy may be associated with a decreased risk of autistic traits in children. Furthermore, adequate vitamin D supplementation could potentially mitigate the impact of phthalates on these traits. Additionally, the proposed biological mechanism provides insight into how phthalate exposure may contribute to the development of ASD.
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