Palladium‐Catalyzed Asymmetric Trifluoromethylated Allylic Alkylation of N‐Substituted Glycine Ethyl Esters with α‐(Trifluoromethyl)alkenyl Acetates

Abstract An efficient strategy for asymmetric trifluoromethylated allylic alkylation of easily available N ‐substituted glycine ethyl esters with α ‐(trifluoromethyl)alkenyl acetates has been developed. Catalyzed by a [Pd(C 3 H 5 )Cl] 2 /( R )‐BINAP, various trifluoromethyl‐containing N ‐substituted glycine ethyl ester derivatives are afforded with good yields and excellent enantioselectivities. The product can be readily converted into diverse fluoro‐substituted species, which shows the practicability of this method.