光敏剂
喜树碱
卟啉
两亲性
单线态氧
超分子化学
光动力疗法
纳米技术
化学
组合化学
药物输送
纳米颗粒
材料科学
生物物理学
光化学
有机化学
分子
生物
共聚物
氧气
聚合物
作者
Shuping Wang,Xuechun Huang,He yun-hong,Haotian Zhang,Jun Zhou,Guping Tang,Shijun Li,Hongzhen Bai
出处
期刊:Nano Today
[Elsevier]
日期:2023-02-01
卷期号:48: 101732-101732
被引量:10
标识
DOI:10.1016/j.nantod.2022.101732
摘要
The development of intelligent nano-platforms with high tumor-targeting capability, enhanced solubility, and efficacious photochemotherapy is urgently demanded for clinical anticancer treatments. Herein, we report an amphiphilic porphyrin (P) to complex with camptothecin (CPT) to form supra-amphiphile-assembled nanoparticles ([email protected]). The host–guest complexation between P and CPT promotes the singlet oxygen production of P and enhances the solubility of CPT, which should be beneficial to improve PDT efficiency and chemotherapy effect. Cancer cell membrane (M) is further used to camouflage [email protected], which endows the resulting [email protected]"M with excellent stability, homologous targeting ability, and specific co-delivering of the chemotherapeutic drug and photosensitizer to tumor cells. The presented work takes advantage of the unique structure and intrinsic performance of P to construct an integrative co-delivery system with the assistance of membrane-coating technology, which not only extends the application scopes of porphyrin photosensitizers but also provides a promising nanoplatform for cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI