Research Progress on the Pharmacological Mechanism of Sour Date Palm in the Treatment of Insomnia with Anxiety and Depression

Insomnia with anxiety and depression is one of the common psychological disorders, which are closely related and usually appear in the form of co-morbidity. The pathogenesis of this disease is still unclear, but it is mostly related to the function of the hypothalamic-pituitary-adrenal axis (HPA axis), neurotransmitter regulation, and inflammatory response. According to Chinese medicine, this disease belongs to the category of "sleeplessness", "depression" and "dirty restlessness", involving the five internal organs and six internal organs. Modern pharmacological studies have shown that sour date kernel contains flavonoids, saponins, triterpenoids, and phenolic acid compounds. It is also found to act simultaneously through sedative-hypnotic, anti-anxiety, anti-depressant, neurotransmitter regulation, inflammation inhibition, and brain nerve protection. In this paper, the pharmacological effects and mechanisms of the active ingredients of Ziziphus jujube were described by reviewing the pharmacological research literature related to Ziziphus jujube, to illustrate the positive efficacy and medicinal value of Ziziphus jujube in the treatment of insomnia with anxiety and depression.