巨噬细胞移动抑制因子
基因型
医学
内科学
单核苷酸多态性
等位基因
多态性(计算机科学)
免疫学
胃肠病学
等位基因频率
病例对照研究
基因
遗传学
生物
细胞因子
作者
Murtadha Ali Hadi,Wijdan Nazar Ibrahim,Meaàd Kadhum Hassan
标识
DOI:10.56875/2589-0646.1091
摘要
Background Hemophilia A, an X-linked bleeding disorder, is caused by a complete or partial deficiency in Factor VIII. Multiple factors play a role in the development and progression of bleeding episodes, especially arthropathy, in hemophilia patients. Objectives Detection of macrophage migration inhibitory factor (MIF)-173 G/C polymorphism in people with hemophilia A (PWH) and the possible associations between the type of MIF gene polymorphism and selected disease-related variables. Subjects and Methods This case–control study included 95 male patients aged 2 months to 63 years with hemophilia A and 95 nonhemophiliac subjects matched for age and sex. Allele-specific polymerase chain reaction (AS-PCR) with multiplex technique was used to detect MIF polymorphisms. Results A significantly higher frequency of GG polymorphism was reported in the control group (81, 85.3%) compared to PWH (64, 67.4%), while a significantly higher frequency of GC polymorphism was found in PWH (21, 22.1%) than in healthy subjects (10, 10.5%), P0.05. Conclusions MIF-173 GC polymorphism is associated with PWH more than healthy individuals. Further studies are required to detect more SNPs through sequencing of MIF gene and to detect MIF serum levels during bleeding episodes.
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