化学
催化作用
钯
氯硅烷
烷基
酰化
还原消去
烯烃
氢化物
有机化学
迁移插入
基质(水族馆)
组合化学
氢
海洋学
硅
地质学
作者
Fei Wu,Bo Wang,Na-Qi Li,Huiyi Yang,Zhi‐Hui Ren,Zheng‐Hui Guan
标识
DOI:10.1038/s41467-023-38748-3
摘要
Novel strategy for acid chlorides formation that do not use carboxylic acids is particularly attractive in chemical synthesis but remains challenging. Herein, we reported the development of a highly effective Pd-catalyzed hydrochlorocarbonylation of alkenes with CO for the formation of alkyl acid chlorides. Chlorosilane and AcOH were found as a mild HCl source for the reaction. The reaction shows broad substrate scope and produces both branched and linear alkyl acid chlorides in good to high yields upon different ligands and solvents. Cooperating with follow-up acylation reactions, the Pd-catalyzed hydrochlorocarbonylation offers a complementary platform for the synthesis of diverse carbonyl compounds from alkenes. Mechanistic investigations suggested that the reaction proceeded though a palladium hydride pathway, and CO prompted reductive elimination of the acyl-Pd-Cl intermediate.
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