Antibiotic Resistance of Biofilm-Related Catheter-Associated Urinary Tract Isolates of Pseudomonas aeruginosa

Catheter-associated urinary tract infections (CAUTI) are one of the most common nosocomial diseases accounting for up to about 23% of healthcare-associated infections. High antibiotic resistance of biofilm-associated bacteria is a serious limiting factor in the treatment of patients. Therefore, the investigations of bacterial biofilms and their regulation can play a pivotal role in the development of new approaches to treating infections. P. aeruginosa is a key bacterium responsible for most urinary tract infections. In this study, urinary catheter–associated P. aeruginosa strains were isolated and their antibiotic resistance was studied. Polymicrobial biofilms were found on the urinary catheter surfaces derived from patients with different urinary tract diseases. Three strains of Pseudomonas aeruginosa isolated from the catheter-associated biofilms were resistant to meropenem. The resistance to carbapenemss of P. aeruginosa strains 96,347 and 96,349 was observed to be mediated by VIM-type metallo-β-lactamase gene expression.