Usher综合征
色素性视网膜炎
感音神经性聋
听力损失
表型
遗传学
疾病
等位基因
医学
基因
生物
听力学
病理
作者
Cécile Courdier,Claire‐Marie Dhaenens,Olivier Grunewald,Anne-Marie Guerrot,Isabelle Audo,A. Lecleire–Collet,Isabelle Amstutz-Montadert,Sophie Gad,G Lapeyre,Xavier Zanlonghi,Dominique Bonneau,Mélanie Fradin,Guylène Le Meur,Sandrine Marlin,Pierre Blanc,Anne‐Françoise Roux,Isabelle Meunier,Vincent Michaud
标识
DOI:10.1080/13816810.2024.2434045
摘要
Introduction Classically, Usher syndrome is characterized by the association of sensorineural hearing loss (SNHL), retinitis pigmentosa (RP) and possible vestibular dysfunction. Pathogenic bi-allelic variants in CEP250 cause atypical autosomal recessive Usher syndrome, which is associated with SNHL and photoreceptors 20 dysfunction without vestibular signs. To date, only 19 scattered descriptions have been reported. In this study, we present detailed clinical and genetic description of 7 unrelated individuals with CEP250 related disease, along with a literature review to provide new insight on the severity and course of the disease.
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