结直肠癌
转移
肿瘤微环境
癌症研究
肿瘤坏死因子α
癌症
医学
化学
肿瘤细胞
免疫学
内科学
作者
Eirik Høye,Chakravarthi Kanduri,Annette Torgunrud,Susanne Lorenz,Bjørn Edwin,Stein Gunnar Larsen,Åsmund Avdem Fretland,Vegar Johansen Dagenborg,Kjersti Flatmark,Christin Lund‐Andersen
摘要
Metastatic colorectal cancer (mCRC) is the main cause of CRC mortality, with limited treatment options. Although immunotherapy has benefited some cancer patients, mCRC typically lacks the molecular features that respond to this treatment. However, recent studies indicate that the immune microenvironment of mCRC may be modified to enhance the effect of immune checkpoint inhibitors. This study aimed to explore the metastatic tumor microenvironment (TME) by comparing cell populations in colorectal liver (CLM), lung (mLu), and peritoneal (PM) metastases.
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