Wearable microfluidic patch with integrated capillary valves and pumps for sweat management and multiple biomarker analysis

微流控 汗水 可穿戴计算机 计算机科学 微通道 生物标志物 纳米技术 材料科学 生物医学工程 化学 嵌入式系统 工程类 生物 生物化学 古生物学
作者
Hengjie Zhang,Ye Qiu,Sihang Yu,Chen Ding,Jiahui Hu,Hangcheng Qi,Ye Tian,Zheng Zhang,Aiping Liu,Huaping Wu
出处
期刊:Biomicrofluidics [American Institute of Physics]
卷期号:16 (4) 被引量:13
标识
DOI:10.1063/5.0092084
摘要

Wearable sweat sensors are essential for providing insight into human physiological health. The currently developed microfluidic sweat sensors have demonstrated the function of collecting and storing sweat. However, they detect more average concentrations of substances based on time periods, which leads to the fact that in situ real-time measurement for multiple biomarkers remains a grand challenge. Here, we propose a wearable epidermal microfluidic patch with integrated microfluidic pumps and micro-valves for accelerated and continuous collection of the sweat, where the micro-pumps ensure the complete separation of old and new sweat for real-time detection of real concentration of biomarkers in sweat. The biomarker concentration at different time periods is detected by introducing a burst valve, which is used to assist in the analysis of the real-time detection. A quantitative relationship between the minimum burst pressure difference required for sequential collection and the size of the microchannel structure is established to overcome the effects of additional resistance at the gas-liquid interface. Additionally, the sensing modules, including sodium ion, chlorine ion, glucose, and pH level in sweat, are integrated into the patch to realize in situ, real-time detection of multiple biomarkers in the human sweat, decoding the correlation between changes in substance concentrations and physiological conditions. This work provides a unique and simplifying strategy for developing wearable sweat sensors for potential applications in health monitoring and disease diagnostics.
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