化学
亲核细胞
亲核取代
催化作用
有机化学
离子液体
氟化物
氟化钾
亲核加成
钾
组合化学
无机化学
作者
Manisha Khandelwal,Gangotri Pemawat,Rama Kanwar Khangarot
标识
DOI:10.1002/ajoc.202200325
摘要
Abstract Fluorinated compounds act as a link between synthetic organic chemistry and medicinal chemistry and compel researchers to explore modified and innovative methods for the syntheses of fluorinated motifs. The identification of reliable and efficient methods for the fluorination of organic moieties remains a major challenge in synthetic organic chemistry. Nucleophilic fluorination reactions using a combination of potassium fluoride (KF) and various catalysts or promoters emerged as a viable strategy and provided access to versatile organofluorine compounds. This review will emphasize recent advancements in nucleophilic fluorination reactions using KF: aliphatic nucleophilic fluorination, aromatic nucleophilic fluorination, and heteroatomic nucleophilic fluorination with ionic liquids, modified crown ethers, and transition metal‐catalysts in various protic and aprotic media.
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