过氧化氢
电子转移
过氧化物酶
工作(物理)
金属有机骨架
化学
氧化酶试验
纳米技术
组合化学
材料科学
酶
化学工程
光化学
有机化学
热力学
物理
吸附
工程类
作者
Sameera Sh. Mohammed Ameen,Khalid M. Omer
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2024-08-15
卷期号:7 (17): 20793-20803
被引量:3
标识
DOI:10.1021/acsanm.4c03725
摘要
The conventional notion is that enzymes, natural and nanozymes, exhibit peak activity solely within defined psychrophilic or thermophilic conditions. This work challenges the notion by preparing a highly efficient oxidase-mimic of Ag-based metal–organic frameworks (MOFs) (referred to as UoZ-3; UoZ stands for University of Zakho), which work effectively in a wide-range of temperatures. This breakthrough not only widens the working temperature range but also overcomes the instability problem of hydrogen peroxide which limited the use of peroxidase-based applications. UoZ-3 showed lower Michaelis–Menten constants compared to silver nanoparticles and silver ions. Surprisingly, the cold/hot adapted UoZ-3 nanozyme exhibited sensitivity to both hydrogen-atom transfer and single-electron transfer reactions with reducing agents, effectively encompassing all of the antioxidant species that are relevant in physiological contexts. Furthermore, the visual-based platform integrated with a smartphone was established and successfully applied for total antioxidant capacity detection in various temperatures in breast cancer patients. The cold/hot adapted oxidase-mimic nanozyme will open an avenue of nanozyme research and applications.
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