MAPK/ERK通路
信号转导
信号通路
受体
细胞生物学
信号
生物
电池类型
细胞
计算生物学
化学
遗传学
作者
Yan Ma,Isabelle Flückiger,Jade Nicolet,Jia Pang,J Dickinson,Damien De Bellis,Aurélia Emonet,Satoshi Fujita,Niko Geldner
标识
DOI:10.1038/s41477-024-01768-y
摘要
Cells harbour numerous receptor pathways to respond to diverse stimuli, yet often share common downstream signalling components. Mitogen-activated protein kinase (MPK) cascades are an example of such common hubs in eukaryotes. How such common hubs faithfully transduce distinct signals within the same cell-type is insufficiently understood, yet of fundamental importance for signal integration and processing in plants. We engineered a unique genetic background allowing direct comparisons of a developmental and an immunity pathway in one cell-type, the Arabidopsis root endodermis. We demonstrate that the two pathways maintain distinct functional and transcriptional outputs despite common MPK activity patterns. Nevertheless, activation of different MPK kinases and MPK classes led to distinct functional readouts, matching observed pathway-specific readouts. On the basis of our comprehensive analysis of core MPK signalling elements, we propose that combinatorial activation within the MPK cascade determines the differential regulation of an endodermal master transcription factor, MYB36, that drives pathway-specific gene activation.
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