暴露的
生物监测
尿
质谱法
化学
聚合物
泌尿系统
纳米技术
计算生物学
环境化学
色谱法
材料科学
医学
生物
生物化学
有机化学
环境卫生
内科学
作者
Guixian Song,Xiaotu Liu,Kenny I. K. Lei,Tiantian Li,Wanbin Li,Da Chen
标识
DOI:10.1021/acs.est.4c01146
摘要
Urinary analysis of exogenous and endogenous molecules constitutes an efficient, noninvasive approach to evaluate human health status. However, the exposome characterization of urinary molecules remains extremely challenging with current techniques. Herein, we develop an ExpoNano strategy based on hyper-cross-linked polymers (HCPs) to achieve ultrahigh-throughput measurement of exo/endogenous molecules in urine. The strategy includes a simple trapping-detrapping procedure (15 min) with HCPs in enzymatically treated urine, followed by mass spectrometer determination. Molecules that can be determined by ExpoNano have a wide range of molecular weight (75-837 Da) and Log
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