基因剔除小鼠
焦虑
星形胶质细胞
神经科学
心理学
细胞生物学
生物
医学
受体
内科学
中枢神经系统
精神科
作者
Joselyn S. Soto,Chiranjivi Neupane,Muskan Kaur,Vijaya Pandey,James A. Wohlschlegel,Baljit S. Khakh
出处
期刊:Neuron
[Cell Press]
日期:2024-08-19
卷期号:112 (20): 3412-3423.e6
被引量:11
标识
DOI:10.1016/j.neuron.2024.07.019
摘要
Astrocytes are morphologically complex cells that serve essential roles. They are widely implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology and gene expression accompanying disease. In the Sapap3 knockout (KO) mouse model of compulsive and anxiety-related behaviors related to obsessive-compulsive disorder (OCD), striatal astrocytes display reduced morphology and altered actin cytoskeleton and Gi-G-protein-coupled receptor (Gi-GPCR) signaling proteins. Here, we show that normalizing striatal astrocyte morphology, actin cytoskeleton, and essential homeostatic support functions by targeting the astrocyte Gi-GPCR pathway using chemogenetics corrected phenotypes in Sapap3 KO mice, including anxiety-related and compulsive behaviors. Our data portend an astrocytic pharmacological strategy for rescuing phenotypes in brain disorders that include compromised astrocyte morphology and tissue support.
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