封锁
光动力疗法
CD47型
癌症治疗
医学
癌症研究
联合疗法
化学
药理学
癌症
受体
内科学
有机化学
作者
Zhaoming Fu,Minghui Feng,Jinxian Wu,Бо Лю,Jiajia Fu,Wen Song
标识
DOI:10.1021/acs.molpharmaceut.4c00254
摘要
The antitumor strategies based on innate immunity activation have become favored by researchers in recent years. In particular, strategies targeting antiphagocytic signaling blockade to enhance phagocytosis have been widely reported. For example, the addition of prophagocytic signals such as calreticulin could make the strategy significantly more effective. In this study, an antitumor strategy that combines photodynamic therapy (PDT) with CD47 blockade has been reported. This approach promotes the maturation of dendritic cells and the presentation of tumor antigens by PDT-mediated tumor immunogenic cell death, as well as the enhancement of cytotoxic T lymphocyte infiltration in tumor areas and the phagocytic activity of phagocytes. Furthermore, the downregulation and blockage of CD47 protein could further promote phagocytic activity, strengthen the innate immune system, and ultimately elevate the antitumor efficacy and inhibit tumor metastasis.
科研通智能强力驱动
Strongly Powered by AbleSci AI