生物
胚泡
PI3K/AKT/mTOR通路
发育阶段
mTOR抑制剂的发现与发展
男科
细胞生物学
胚胎
癌症研究
胚胎发生
信号转导
医学
心理学
发展心理学
作者
Dhanur P Iyer,Heidar Heidari Khoei,Vera A. van der Weijden,Harunobu Kagawa,Saurabh J. Pradhan,Maria Novatchkova,Afshan McCarthy,Teresa Rayón,Claire Simon,Ilona Dunkel,Sissy E. Wamaitha,Kay Elder,Phil Snell,Leila Christie,Edda G. Schulz,Kathy K. Niakan,Nicolas Rivron,Aydan Bulut-Karslıoğlu
出处
期刊:Cell
[Elsevier]
日期:2024-09-01
标识
DOI:10.1016/j.cell.2024.08.048
摘要
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here, we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. The pacing of human blastocyst development has potential implications for reproductive therapies.
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