清脆的
体内
癌症的体细胞进化
转化(遗传学)
表型
细胞
生物
恶性转化
计算生物学
癌症研究
遗传学
基因
作者
Peter F. Renz,Umesh Ghoshdastider,Simona Baghai Sain,Fabiola Valdivia-Francia,Ameya Khandekar,Mark L. Ormiston,Martino Bernasconi,Clara Duré,Jonas A. Kretz,Minkyoung Lee,Katie Hyams,Merima Forny,Marcel Pohly,Xenia Ficht,Stephanie J. Ellis,Andreas E. Moor,Ataman Sendoel
出处
期刊:Nature
[Springer Nature]
日期:2024-07-17
卷期号:632 (8024): 419-428
被引量:1
标识
DOI:10.1038/s41586-024-07663-y
摘要
The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can remodel entire tissues
科研通智能强力驱动
Strongly Powered by AbleSci AI