Study of Macular Thickness Using Spectral Domain Optical Coherence Tomography in Healthy Indian Subjects

Purpose: To generate normative data for SD-OCT (Topcon 3D OCT 2000) estimated macular thickness in Indian eyes and establish its relation with age sex and refractive error.Materials and methods: In this cross sectional , observational, hospital based study 800 eyes of 400 healthy Indian individuals underwent a macula OCT scan using Topcon SD OCT.Macular thickness was measured in 9 ETDRS regions .The effect of age , sex , refractive error on foveal thickness was determined.Results: The mean central foveeal thickness was 226.4025 ±22.5063 μm.Males were found to have a significantly thicker macula (P< 0.05) than females with the central foveal thickness of 229.8153 ± 21.4222 vs 220.7748 ±23.14742 .Central foveal thickness was found to have very weak correlation with age which was not statistically significant.All other regions (the parafoveal and perifoveal thickness) showed statistically significant negative correlation with age. Conclusion:We provide the largest normative data for SD OCT Topcon 3D OCT 2000.We also suggest that demographic factor like gender should be considered while interpreting any OCT measurements.The normal range of central macular thickness for Indian population should be 181 µm to 270 µm for Topcon SD OCT.Age and refractive error do not show a significant correlation with central macular thickness.