酪氨酸羟化酶
儿茶酚胺
发病机制
交感神经系统
医学
内分泌学
内科学
酪氨酸3-单加氧酶
病理生理学
酪氨酸
限制
调节器
血压
多巴胺
生物
基因
遗传学
生物化学
工程类
机械工程
作者
Yu Ho Lee,Yang‐Gyun Kim,Jae‐Young Moon,Jin Sug Kim,Kyung-Hwan Jeong,Tae Won Lee,Chun-Gyoo Ihm,Sang Ho Lee
出处
期刊:Electrolyte & Blood Pressure
[The Korean Society of Electrolyte Metabolism]
日期:2016-01-01
卷期号:14 (2): 21-21
被引量:9
标识
DOI:10.5049/ebp.2016.14.2.21
摘要
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.
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