Global warming is expected to change the wind and wave patterns at a significant level, which may lead to conditions outside current design criteria of monopile supported offshore wind turbine (OWT). This study examines the impact of climate change on the dynamic behavior and future safety of an OWT founded in clay incorporating dynamic soil–structure interaction. A statistical downscaling model is used to generate the time series of future wind speed and wave height at local level. The responses and fatigue life of OWT are estimated for present and future periods and extent of change in design is investigated at offshore location along the west coast of India. Wind speed, wave height, and wave period data are collected from the buoy deployed by Indian National Centre for Ocean Information Services and the future climate for the next 30 years is simulated using the general circulation model corresponding to Special Report on Emission Scenarios A1B scenario. The OWT is modeled as Euler–Bernoulli beam and soil–structure interaction is incorporated using nonlinear p-y springs. This study shows that changes in design of OWT are needed due to increased responses owing to the effect of climate change. Fatigue life is found to be decreased because of climate change.