纳米棒
荧光
材料科学
纳米技术
量子点
量子产额
纳米颗粒
碳纤维
光致发光
化学工程
光电子学
复合数
复合材料
量子力学
物理
工程类
作者
Baojin Ma,Shan Zhang,Ruo-Yu Liu,Jichuan Qiu,Lili Zhao,Shicai Wang,Jianhua Li,Yuanhua Sang,Huaidong Jiang,Hong Liu
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2016-10-27
卷期号:9 (6): 2162-2171
被引量:45
摘要
Carbon quantum dots (CQDs) are a new type of fluorescent nanoparticle for cell imaging and tracking. However, they would easily diffuse and quench, followed by the loss of their fluorescence ability. By connecting their functional groups with other nanoparticles, the CQDs will be protected from destruction and exhibit long-time fluorescence. Here, carbon quantum dot–hydroxyapatite (CQD–HAp) hybrid nanorods were prepared by the self-assembly of CQDs on the surface of HAp nanorods through a facile one-pot process. The morphology and size of the CQD–HAp hybrid nanorods can be well controlled by using oleic acid, which meanwhile is the source of CQDs. The hydrophilic CQD–HAp hybrid nanorods have prolonged fluorescence life due to the connection between CQDs and HAp nanorods, and exhibit a higher fluorescence quantum yield than pure CQDs. In addition, when hybrid nanorods load doxorubicin (Dox) to form Dox–CQD–HAp hybrid nanorods, they can more efficiently kill human cervical cancer (HeLa) cells, rather than human prostatic cancer (PC-3) cells. Long time fluorescence for cell imaging and high efficiency in killing cancer cells as a drug-delivery medium make CQD–HAp hybrid nanorods have great potential applications in the bio-field.
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