商业化
生化工程
尺寸
纳米技术
均质化(气候)
计算机科学
化学
工艺工程
材料科学
业务
工程类
生态学
生物
生物多样性
营销
有机化学
作者
Sachin Kumar Singh,Yogyata Vaidya,Monica Gulati,Sibasis Bhattacharya,Varun Garg,Narendra Kumar Pandey
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2016-11-08
卷期号:13 (8): 1222-1246
被引量:33
标识
DOI:10.2174/1567201813666160101120452
摘要
In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose. The unique inherent properties of nanosuspensions have been explored for a wide variety of applications. Commercial production of stable nanosuspensions has been made possible by the use of techniques such as media milling and high pressure homogenization. This article reviews various techniques being employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to overcome their stability and commercialization related aspects are also highlighted. Keywords: Bottom up technology, Characterization, High pressure homogenization, Media milling, Nanosuspension, Stability.
科研通智能强力驱动
Strongly Powered by AbleSci AI