Oxcarbazepine‐induced liver injury after sensitization by valproic acid: a case report

Objective The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury. Methods We report the case of a 46‐year‐old man with schizoaffective disorder who was cross‐titrated from valproic acid to oxcarbazepine because of liver injury. Results Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later. Conclusions Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.