勃起功能障碍
内皮功能障碍
医学
内皮
遗传增强
肺动脉高压
干细胞疗法
干细胞
生物信息学
内皮干细胞
内科学
心脏病学
移植
生物
基因
遗传学
体外
作者
Bobby D. Nossaman,Serap Gür,Philip J. Kadowitz
标识
DOI:10.2174/156652307780363161
摘要
The endothelium has an important regulatory role in the maintenance of vascular homeostasis, vascular tone, blood flow, and in preserving a non-thrombogenic blood-tissue interface. Injury to the vascular wall with subsequent endothelial dysfunction alters these important regulatory functions leading to a state of abnormal endothelial function. In this paper, we review the pathophysiology of endothelial dysfunction and how this disorder is common to the development of erectile dysfunction and of pulmonary arterial hypertension. Current medical therapies for these two disorders are discussed followed by a review of the preclinical studies involving currently available strategies for gene and stem cell therapy and their potential for the clinical treatment of these two disorders of endothelial dysfunction. Keywords: Endothelium, vascular/pp, impotence/et, male, risk factors, pulmonary hypertension/dt, cardiovascular diseases/dt, gene therapy/mt, adult, aging/pa
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