抗菌剂
阳离子聚合
化学
抗生素耐药性
抗菌肽
圆二色性
肽
抗生素
抗菌活性
金黄色葡萄球菌
鲍曼不动杆菌
最小抑制浓度
体外
抗药性
抗菌剂
组合化学
体内
多重耐药
立体化学
微生物学
结构-活动关系
生物化学
有机化学
生物
作者
Diego Faccone,Omar Veliz,Alejandra Corso,Martín Ezequiel Noguera,Melina María Belén Martínez,Cristian Payés,Liliana Semorile,Paulo Cesar Maffia
标识
DOI:10.1016/j.ejmech.2013.10.065
摘要
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
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