Synthesis of Oximes with NH2OH.HCl/DOWEX(R)50WX4 System

Abstract The oximation of a variety of carbonyl compounds was efficiently carried out with DOWEX(R)50WX4/NH 2 OH·HCl system. The reactions were performed in ethanol to give Z ‐aldoximation isomers of aldehydes and E ‐oximaton of acetophenone derivatives in a perfect selectively. The oximation of compounds with two carbonyl groups was carried out selectively on one carbonyl moiety. Also, the oximation of aldehydes over ketones has been accomplished successfully by this system.