芳香烃受体
转录因子
免疫系统
受体
生物
获得性免疫系统
免疫
内生
细胞生物学
化学
免疫学
生物化学
基因
作者
Francisco J. Quintana,David H. Sherr
出处
期刊:Pharmacological Reviews
[American Society for Pharmacology & Experimental Therapeutics]
日期:2013-08-01
卷期号:65 (4): 1148-1161
被引量:279
标识
DOI:10.1124/pr.113.007823
摘要
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that belongs to the family of basic helix-loop-helix transcription factors. Although the AhR was initially recognized as the receptor mediating the pathologic effects of dioxins and other pollutants, the activation of AhR by endogenous and environmental factors has important physiologic effects, including the regulation of the immune response. Thus, the AhR provides a molecular pathway through which environmental factors modulate the immune response in health and disease. In this review, we discuss the role of AhR in the regulation of the immune response, the source and chemical nature of AhR ligands, factors controlling production and degradation of AhR ligands, and the potential to target the AhR for therapeutic immunomodulation.
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