地塞米松
生物利用度
药代动力学
医学
口服
给药途径
皮质类固醇
药理学
内科学
作者
Gábor G. Tóth,Christiaan Kloosterman,Donald Uges,Marcel F. Jonkman
出处
期刊:Therapeutic Drug Monitoring
[Ovid Technologies (Wolters Kluwer)]
日期:1999-10-01
卷期号:21 (5): 532-532
被引量:44
标识
DOI:10.1097/00007691-199910000-00007
摘要
Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was assessed by comparing the areas under the serum concentration-time curves following oral administration with those of intravenous administration. Mean bioavailability of high-dose oral dexamethasone was 63.4%. Side effects were minor and were limited to temporary facial flushing both after oral and intravenous administration. Oral administration of dexamethasone in pemphigus patients showed to be more convenient and cost effective than administration by the intravenous route.
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