硝酸异山梨酯
色谱法
聚乙二醇
增塑剂
甘露醇
溶解
生物利用度
明胶
剂型
异山梨酯
溶解试验
干粉吸入器
冷冻干燥
医学
药理学
材料科学
化学
生物制药分类系统
有机化学
吸入器
麻醉
哮喘
复合材料
内科学
作者
Mitra Alami-Milani,Sara Salatin,Elaheh Nasiri,Mitra Jelvehgari
标识
DOI:10.4155/tde-2020-0127
摘要
Background: Orally disintegrating tablets rapidly disintegrate in saliva and then swallowed without the need for water. Materials & methods: The orally disintegrating tablets were prepared by freeze-drying of an aqueous dispersion of isosorbide dinitrate containing a matrix former (gelatin), a cryoprotectant (mannitol), a plasticizer (glycerin) and a dissolution enhancer (Tween/polyethylene glycol). Results: Results demonstrated that the selected formulation, Ft9, disintegrated within 1 min and showed faster dissolution rate compared with the commercial tablet. Conclusion: Having a fast disintegration time, the developed lyophilized tablet does not need to be swallowed as a whole. So, it is a convenient solid oral dosage form for the patients who have difficulty with swallowing such as the pediatric and elderly ones.
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