Single Institution Experience with Afirma and Thyroseq Testing in Indeterminate Thyroid Nodules

甲状腺结节 不确定 医学 恶性肿瘤 卡帕 甲状腺 组织病理学 回顾性队列研究 细针穿刺 细胞学 放射科 内科学 病理 活检 纯数学 哲学 语言学 数学
作者
Michele Gortakowski,Krystel Feghali,Ibitoro Osakwe
出处
期刊:Thyroid [Mary Ann Liebert, Inc.]
卷期号:31 (9): 1376-1382 被引量:25
标识
DOI:10.1089/thy.2020.0801
摘要

Background: Thyroid nodules are a very common often incidental finding on physical examination or imaging. Of those who undergo fine needle aspiration, cytology is indeterminate in up to 15%. Molecular testing is increasingly being used to help identify which nodules may be high risk for malignancy and guide management with regard to clinical follow-up or surgical intervention. Recently there has been an increase in publication of independent studies assessing the performance of these molecular tests and comparing "real-world" data with the validation studies. Methods: This retrospective study identified all thyroid nodules at our institution that had Afirma gene expression classifier (GEC), genomic sequencing classifier (GSC), or Thyroseq v3 molecular testing from January 2014 to January 2020 and compared measurements of test performance between them at our institution, and then with the original validation studies and other published institutional data. Results: Overall, the benign call rate was highest in the Afirma GSC group (78%) compared with the GEC group (60%) and Thyroseq group (66%). Surgical histopathology revealed malignancy in 6 of 31of biopsied nodules in the GEC group, 8 of 13 in the GSC group, and 3 of 16 in the Thyroseq v3 group. Based on our data, the GSC specificity (73.7%) and positive predictive value (PPV) (61.5%) were higher than the GEC specificity (60.4%) and PPV (22.2%) as well as Thyroseq v3 specificity (55.2%) and PPV (18.8%). Conclusions: From our short-term institutional experience, we found that the GSC classified more cytologically indeterminate nodules as benign compared with the Afirma GEC, and had improved specificity and PPV, which is similar to the validation study and other institutions' reported experiences. We also found that the Thyroseq v3 was similar to the Afirma GEC in terms of specificity and PPV, both of which are much lower than the validation studies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
iNk应助今何在采纳,获得10
刚刚
西粤学发布了新的文献求助10
1秒前
薛之谦完成签到,获得积分10
2秒前
LaFee完成签到,获得积分10
4秒前
鑫鑫完成签到,获得积分10
4秒前
甚也完成签到 ,获得积分10
4秒前
ZZH完成签到,获得积分10
5秒前
mr完成签到 ,获得积分10
6秒前
今何在完成签到,获得积分10
6秒前
GY916完成签到 ,获得积分20
6秒前
Fly完成签到 ,获得积分10
7秒前
科目三应助黄超超采纳,获得10
7秒前
量子星尘发布了新的文献求助10
8秒前
Jason完成签到,获得积分10
9秒前
9秒前
歪比巴卜完成签到,获得积分10
10秒前
卿卿完成签到,获得积分20
11秒前
云墨完成签到 ,获得积分10
11秒前
SilentStorm完成签到,获得积分10
11秒前
12秒前
13秒前
sunnyfriend完成签到,获得积分10
13秒前
xiaozang完成签到,获得积分10
14秒前
怕黑寻雪完成签到 ,获得积分10
14秒前
15秒前
李白完成签到,获得积分10
16秒前
正直涵菱发布了新的文献求助10
16秒前
感性的酬海完成签到,获得积分10
17秒前
王王的狗子完成签到 ,获得积分10
17秒前
innyjiang完成签到,获得积分10
19秒前
陆王牛马完成签到 ,获得积分10
20秒前
20秒前
Ava应助念念采纳,获得10
21秒前
LIAO完成签到,获得积分10
21秒前
迅速凝竹完成签到 ,获得积分10
23秒前
妮妮完成签到,获得积分10
24秒前
24秒前
哈哈哈完成签到,获得积分20
25秒前
快乐随心完成签到 ,获得积分10
26秒前
了一李完成签到 ,获得积分10
26秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029