Fe(II)-driven self-assembly of enzyme-like coordination polymer nanoparticles for cascade catalysis and wound disinfection applications

A kind of coordination polymer nanoparticles was facily prepared using Fe(II) and GMP as the motifs through a coordination-driven self-assembly process. The resultant Fe-GMP CPNs show excellent peroxidase-like activity via the conversion of H 2 O 2 into OH, accompanied by high antibacterial efficiency. GOX could be adaptively encapsulated into Fe-GMP CPNs, and the proposed GOX@Fe-GMP CPNs functioned as an enzyme cascade model with a glucose-responsive property in OH production, with excellent antibacterial and wound disinfection efficiency under physiological conditions. • Self-assemblied coordination polymer nanoparticles were prepared using Fe(II) and GMP. • The Fe-GMP CPNs show excellent peroxidase-like activity through OH production. • The Fe-GMP CPNs indicated high antibacterial efficiency for E. coli and S. aureus . • The prepared GOX@Fe-GMP CPNs functioned as an enzyme cascade model in OH production. • GOX@Fe-GMP CPNs have excellent antibacterial and wound disinfection efficiency. The intelligent regulation of reactive oxygen species by nanozymes and the corresponding cascade catalysis hold great potential as a promising next-generation therapeutic methodology. However, the preparation of nanozymes usually involves high material consumption and tedious multistep processes, especially during the packaging of several functional components to realize the enzyme cascade. Here, we propose a facile strategy to prepare the coordination polymer nanoparticles (CPNs) using ferrous ions as the iron source and guanosine monophosphate (GMP) as the supramolecular motif. The resultant Fe-GMP CPNs show excellent peroxidase-like activity via the conversion of H 2 O 2 into highly active OH, accompanied by high antibacterial efficiency, as well as high encapsulation capacity to simultaneously immobilize guest components through an adaptive self-assembly process. Typically, glucose oxidase (GOX) encapsulation endows as-prepared GOX@Fe-GMP CPNs with glucose-responsive properties, so that glucose can be ultimately converted into OH via intermediate H 2 O 2 . This convenient cascade catalysis system not only possesses excellent antibacterial efficiencies, inhibiting the growth of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) by 99% and significantly promoting wound healing in the absence of additional H 2 O 2 , but also has great application potential in the fields of biocatalysis and biomedicine.