连接器
肽
结合
化学
双功能
表面改性
组合化学
生物物理学
癌细胞
作者
Jacky C.H. Chu,Chihao Shao,Summer Y. Y. Ha,Wing-Ping Fong,Clarence Tsun Ting Wong,Dennis K. P. Ng
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2021-11-02
被引量:1
摘要
We report herein a one-pot approach to cyclise a tumour-targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications.
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