Dexmedetomidine down-regulates lncRNA MALAT1 to attenuate myocardial ischemia reperfusion-induced injury by increasing miR-346

Zheng et al. [ [1] Zheng X. Li J. Fan Q. Zhao X. Chen K. Dexmedetomidine alleviates myocardial ischemia/reperfusion-induced injury and Ca(2+) overload via the microRNA-346-3p/CaMKIId axis. Int. J. Cardiol. 2021; (Online ahead of print) Abstract Full Text Full Text PDF Scopus (5) Google Scholar ] reported that dexmedetomidine attenuated myocardial ischemia reperfusion-induced injury (MI/R injury) via up-regulating miR-346 expression and then inhibited the CaMKIId/NF-κB/NLRP3 inflammasome pathway activation. This finding may recognize a novel therapy of dexmedetomidine for MI/R injury, whereas the mechanisms of dexmedetomidine-induced miR-346 expression need further exploration.